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Beilstein J. Org. Chem. 2014, 10, 7–11, doi:10.3762/bjoc.10.2
Graphical Abstract
Scheme 1: Proposed steps for DNA demethylation (for details see text).
Figure 1: Structures of the synthesized compounds.
Scheme 2: Synthesis of the 2'-deoxycytidine analogues.
Scheme 3: Reactions of TCBoc-protected aldehydes 4 and 5 with organometallic reagents.
Scheme 4: Proposed mechanism for the formation of 3,6-dihydrodeoxycytidine derivatives 8a–d (M = Li, Mg).
Beilstein J. Org. Chem. 2013, 9, 2328–2335, doi:10.3762/bjoc.9.267
Figure 1: Structures of cyclopamine and exo-cyclopamine.
Scheme 1: Synthesis of 25-epi-exo-cyclopamine 5, bis-exo-cyclopamine 6, and derivatives 8 and 9. Reaction con...
Scheme 2: Synthesis of 20-demethyl-bis-exo-cyclopamine 19 and F-nor-20,25-bis-demethyl-exo-cyclopamine 23. Re...
Figure 2: IC50 values of Shh inhibition by compounds 5, 6 and 23 in a Gli1-reporter gene assay. Data were obt...